Fundamental Studies on Colony Formation of Erythroid Progenitor Cells
نویسندگان
چکیده
منابع مشابه
Development of Erythroid Progenitor Cells
Erythropoietin (EP), insulin-like growth factor I (IGF-I) and stem cell factor (SCF) each reduce apoptosis of human erythroid progenitor cells. To determine if these growth factors have additional roles in stimulating erythropoiesis, the proliferation, maturation, and survival of highly purified human erythroid colony-forming cells (ECFCs) were studied during the application of different combin...
متن کاملEffect of L-carnitine on erythroid colony formation in mouse bone marrow cells.
BACKGROUND l-Carnitine can alleviate uraemic anaemia in haemodialysis patients by improving erythrocyte membrane functions or erythropoiesis, which are depressed under uraemic conditions. l-Carnitine and palmitoyl-l-carnitine were reported to increase the formation of colony-forming unit-erythroid (CFU-E) colonies in cultures of fetal mouse liver cells, an effect that depended on the concentrat...
متن کاملEffects of Granulocyte - Macrophage Colony - Stimulating Factor and Erythropoietin on Leukemic Erythroid Colony Formation in Human
Erythroid colonies from five patients with an early erythroblastic leukemia were obtained in “serum-free” cultures in the presence or absence of recombinant granulocytemacrophage colony-stimulating factor (GM-CSF) and homogeneous native erythropoietin (Epo). Erythroid colenies with abnormal morphology and karyotype could be grown in different culture conditions. Their erythroid nature was ascer...
متن کاملHuman erythroid progenitor cells express Rhesus antigens.
The expression of Rhesus antigens on hematopoietic progenitor cells was studied using monoclonal antibodies. Because these antibodies are not capable of lysing mature red blood cells in a complement-dependent cytotoxicity assay, fluorescence-activated cell sorting was performed. Using the monoclonal anti-Rh 29 antibody B10, 68% +/- 6% of the mature erythroid progenitor cells (CFU-E) were sorted...
متن کاملAbnormal erythroid progenitor cells in human preleukemia.
Ten patients with preleukemia were studied by the erythroid cell clonal culture technique. In nine of these patients, erythroid colonies derived from peripheral blood BFU-E were not observed, while the other patient had markedly decreased peripheral blood BFU-E-derived erythroid colonies in vitro. In three patients, marrow cells were also cultured and no BFU-E-derived erythroid colonies were de...
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ژورنال
عنوان ژورنال: Journal of UOEH
سال: 1986
ISSN: 0387-821X,2187-2864
DOI: 10.7888/juoeh.8.185